TwinCons: Conservation score for uncovering deep sequence similarity and divergence.

ABSTRACT: We have developed the program TwinCons, to detect noisy signals of deep ancestry of proteins or nucleic acids. As input, the program uses a composite alignment containing pre-defined groups, and mathematically determines a 'cost' of transforming one group to the other at each position of the alignment. The output distinguishes conserved, variable and signature positions. A signature is conserved within groups but differs between groups. The method automatically detects continuous characteristic stretches (segments) within alignments. TwinCons provides a convenient representation of conserved, variable and signature positions as a single score, enabling the structural mapping and visualization of these characteristics. Structure is more conserved than sequence. TwinCons highlights alternati

SUBMITTER: Penev PI 

PROVIDER: S-EPMC8580257 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature