High-sucrose diets contribute to brain angiopathy with impaired glucose uptake and psychosis-related higher brain dysfunctions in mice.
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ABSTRACT:
SUBMITTER: Hirai S
PROVIDER: S-EPMC8580307 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
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High-sucrose diets contribute to brain angiopathy with impaired glucose uptake and psychosis-related higher brain dysfunctions in mice.
Hirai Shinobu S Miwa Hideki H Tanaka Tomoko T Toriumi Kazuya K Kunii Yasuto Y Shimbo Hiroko H Sakamoto Takuya T Hino Mizuki M Izumi Ryuta R Nagaoka Atsuko A Yabe Hirooki H Nakamachi Tomoya T Shioda Seiji S Dan Takashi T Miyata Toshio T Nishito Yasumasa Y Suzuki Kazuhiro K Miyashita Mitsuhiro M Tomoda Toshifumi T Hikida Takatoshi T Horiuchi Junjiro J Itokawa Masanari M Arai Makoto M Okado Haruo H
Science advances 20211110 46
Metabolic dysfunction is thought to contribute to the severity of psychiatric disorders; however, it has been unclear whether current high–simple sugar diets contribute to pathogenesis of these diseases. Here, we demonstrate that a high-sucrose diet during adolescence induces psychosis-related behavioral endophenotypes, including hyperactivity, poor working memory, impaired sensory gating, and disrupted interneuron function in mice deficient for glyoxalase-1 (GLO1), an enzyme involved in detoxif ...[more]
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