Analysis of gut microbiota and metabolites in patients with rheumatoid arthritis and identification of potential biomarkers.

ABSTRACT: Rheumatoid arthritis (RA) is an autoimmune disease described by joint destruction, synovitis and pannus formation. The gut microbiota acts as an environmental factor that plays an important role in RA, but little research regarding the etiopathogenic mechanisms of the microbiome in RA has been carried out. We used an integrated approach of 16S rRNA gene sequencing and ultrahigh-performance liquid chromatography-mass spectrometry-based metabolomics to analyze the structure and diversity of the intestinal flora and metabolites of the gut microbiota in RA patients compared with healthy subjects. In this study, α-diversity analysis of the gut microbiota showed that there was no significant difference between the healthy control (HC) and RA groups. However, β-diversity analysis showed that ther

SUBMITTER: Chen Y 

PROVIDER: S-EPMC8580343 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature