AHNAK suppresses ovarian cancer progression through the Wnt/β-catenin signaling pathway.

ABSTRACT: Globally, ovarian cancer is the 2^nd most frequent cause of gynecologic-associated cancer fatalities among women. It has an unfavorable prognosis. There is a need to elucidate on the mechanisms involved in ovarian cancer progression and to identify novel cancer targets. We investigated and verified AHNAK contents in ovarian cancer tissues and corresponding healthy tissues. Then, we overexpressed AHNAK in vitro and in vivo to establish the roles of AHNAK in ovarian cancer cell proliferation and metastasis. Finally, we evaluated the possible molecular mechanisms underlying. We established that AHNAK was downregulated in ovarian cancer. Elevated AHNAK contents in ovarian cancer cell lines remarkably repressed ovarian cancer cell growth, along with metastasis in vitr

SUBMITTER: Cai Y 

PROVIDER: S-EPMC8580348 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature