CD4⁺ T-Cell Activation Prompts Suppressive Function by Extracellular Vesicle-Associated MicroRNAs.

ABSTRACT: MicroRNAs (miRNAs), small non-coding molecules targeting messenger RNAs and inhibiting protein translation, modulate key biological processes, including cell growth and development, energy utilization, and homeostasis. In particular, miRNAs control the differentiation, survival, and activation of CD4 ⁺ T conventional (Tconv) cells, key players of the adaptive immunity, and regulate the physiological response to infections and the pathological loss of immune homeostasis in autoimmunity. Upon T-cell receptor (TCR) stimulation, the described global miRNA quantitative decrease occurring in T cells is believed to promote the acquisition of effector functions by relaxing the post-transcriptional repression of genes associated with proliferation and cell activity. MiRNAs were in

SUBMITTER: Di Silvestre D 

PROVIDER: S-EPMC8580371 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature