Echinacoside Upregulates Sirt1 to Suppress Endoplasmic Reticulum Stress and Inhibit Extracellular Matrix Degradation In Vitro and Ameliorates Osteoarthritis In Vivo.

ABSTRACT:

Background

Osteoarthritis (OA) is a progressive illness that destroys cartilage. Oxidative stress is a major contributor of OA, while endoplasmic reticulum (ER) stress is the key cellular damage under oxidative stress in chondrocytes. Echinacoside (ECH) is the main extract and active substance of Cistanche, with potent antioxidative stress (OS) properties, and currently under clinical trials in China. However, its function in OA is yet to be determined.

Purpose

We aimed to explore the specific role of ECH in the occurrence and development of OA and its underlying mechanism in vivo and in vitro.

Methods

After the mice were anesthetized, the bilateral medial knee joint meniscus resection was performed to establish the DMM model. TBHP was used to ind

SUBMITTER: Lin Z 

PROVIDER: S-EPMC8580641 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature