B-cell activating factor BAFF as a novel alert marker for the immunological risk stratification after kidney transplantation.

ABSTRACT: The B cell activating factor BAFF has gained importance in the context of kidney transplantation due to its role in B cell survival. Studies have shown that BAFF correlates with an increased incidence of antibody-mediated rejection and the development of donor-specific antibodies. In this study, we analyzed a defined cohort of kidney transplant recipients who were treated with standardized immunosuppressive regimens according to their immunological risk profile. The aim was to add BAFF as an awareness marker in the course after transplantation to consider patient's individual immunological risk profile. Included patients were transplanted between 2016 and 2018. Baseline data, graft function, the occurrence of rejection episodes, signs of microvascular infiltration, and DSA kinetics were re

SUBMITTER: Schuster AM 

PROVIDER: S-EPMC8580904 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature