Swiprosin-1 deficiency in macrophages alleviated atherogenesis.

ABSTRACT: Macrophages play a vital role in the development of atherosclerosis. Previously, we have found that swiprosin-1 was abundantly expressed in macrophages. Here, we investigated the role of swiprosin-1 expressed in macrophages in atherogenesis. Bone marrow transplantation was performed from swiprosin-1-knockout (Swp^-/-) mice and age-matched ApoE^-/- mice. Atherosclerotic lesion, serum lipid, and interleukin-β (IL-β) levels were detected. In vitro, the peritoneal macrophages isolated from Swp^-/- and wild-type mice were stimulated with oxidized low-density lipoprotein (ox-LDL) and the macrophage of foam degree, cellular lipid content, apoptosis, inflammatory factor, migration, and autophagy were determined. Our results showed that swiprosin-1 was mainly expressed

SUBMITTER: Tong LC 

PROVIDER: S-EPMC8580969 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature