Elevated circulating follistatin associates with an increased risk of type 2 diabetes.
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ABSTRACT:
SUBMITTER: Wu C
PROVIDER: S-EPMC8580990 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
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Elevated circulating follistatin associates with an increased risk of type 2 diabetes.
Wu Chuanyan C Borné Yan Y Gao Rui R López Rodriguez Maykel M Roell William C WC Wilson Jonathan M JM Regmi Ajit A Luan Cheng C Aly Dina Mansour DM Peter Andreas A Machann Jürgen J Staiger Harald H Fritsche Andreas A Birkenfeld Andreas L AL Tao Rongya R Wagner Robert R Canouil Mickaël M Hong Mun-Gwan MG Schwenk Jochen M JM Ahlqvist Emma E Kaikkonen Minna U MU Nilsson Peter P Shore Angela C AC Khan Faisel F Natali Andrea A Melander Olle O Orho-Melander Marju M Nilsson Jan J Häring Hans-Ulrich HU Renström Erik E Wollheim Claes B CB Engström Gunnar G Weng Jianping J Pearson Ewan R ER Franks Paul W PW White Morris F MF Duffin Kevin L KL Vaag Allan Arthur AA Laakso Markku M Stefan Norbert N Groop Leif L De Marinis Yang Y
Nature communications 20211110 1
The hepatokine follistatin is elevated in patients with type 2 diabetes (T2D) and promotes hyperglycemia in mice. Here we explore the relationship of plasma follistatin levels with incident T2D and mechanisms involved. Adjusted hazard ratio (HR) per standard deviation (SD) increase in follistatin levels for T2D is 1.24 (CI: 1.04-1.47, p < 0.05) during 19-year follow-up (n = 4060, Sweden); and 1.31 (CI: 1.09-1.58, p < 0.01) during 4-year follow-up (n = 883, Finland). High circulating follistatin ...[more]
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