Replication study and meta-analysis of selected genetic variants and polycystic ovary syndrome susceptibility in Asian population.

ABSTRACT:

Purpose

Polycystic ovary syndrome (PCOS) is a highly complex disorder influenced by genetic and environmental factors. Previous association studies have identified multiple PCOS-susceptible loci, but there is no consistent conclusion, which calls for further investigations.

Methods

In the present case-control study, FSHR gene variants (rs2268361, rs6165, and rs6166), LHCGR gene variant (rs13405728), THADA gene variant (rs13429458), DENND1A gene variants (rs10818854 and rs2479106), and INSR gene variants (rs2059807 and rs1799817) were genotyped with Sanger sequencing in a total of 400 PCOS women and 480 healthy women.

Results

After Bonferroni correction, our results showed that rs13405728, rs13429458, rs2479106, rs10818854, and rs2059807 were significantly associated w

SUBMITTER: Wan P 

PROVIDER: S-EPMC8581112 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature