Development and Verification of Glutamatergic Synapse-Associated Prognosis Signature for Lower-Grade Gliomas.

ABSTRACT: Background: Lower-grade glioma (LGG) is the most common histology identified in gliomas, a heterogeneous tumor that may develop into high-grade malignant glioma that seriously shortens patient survival time. Recent studies reported that glutamatergic synapses might play an essential role in the progress of gliomas. However, the role of glutamatergic synapse-related biomarkers in LGG has not been systemically researched yet. Methods: The mRNA expression data of glioma and normal brain tissue were obtained from The Cancer Genome Atlas database and Genotype-Tissue Expression, respectively, and the Chinese Glioma Genome Atlas database was used as a validation set. Difference analysis was performed to evaluate the expression pattern of glutamatergic synapse-related genes (GSRGs) i

SUBMITTER: Ye L 

PROVIDER: S-EPMC8581158 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature