Optimal Cerebral Perfusion Pressure Guided by Brain Oxygen Pressure Measurement.

ABSTRACT: Background: Although increasing cerebral perfusion pressure (CPP) is commonly accepted to improve brain tissue oxygen pressure (PbtO₂), it remains unclear whether recommended CPP targets (i. e., >60 mmHg) would result in adequate brain oxygenation in brain injured patients. The aim of this study was to identify the target of CPP associated with normal brain oxygenation. Methods: Prospectively collected data including patients suffering from acute brain injury and monitored with PbtO₂, in whom daily CPP challenge using vasopressors was performed. Initial CPP target was >60 mmHg; norepinephrine infusion was modified to have an increase in CPP of at least 10 mmHg at two different steps above the baseline values. Whenever possible, the same CPP challenge was

SUBMITTER: Kovacs M 

PROVIDER: S-EPMC8581172 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature