Establishment of tumor inflammasome clusters with distinct immunogenomic landscape aids immunotherapy.

ABSTRACT: Inflammasome signaling is a reaction cascade that influences immune response and cell death. Although the inflammasomes participate in tumorigenesis, their role as an oncogenic booster or a tumor suppresser is still controversial. Therefore, it is important to comprehensively investigate the inflammasome signaling status across various cancers to clarify its clinical and therapeutic significance. Methods: A total of 9881 patients across 33 tumor types from The Cancer Genome Atlas database were included in this study. Five gene sets were identified to step-wisely profile inflammasome signaling. Unsupervised clustering was used for sample classification based on gene set enrichment. Machine learning and in vitro and in vivo experiments were used to confirm the implicatio

SUBMITTER: Liang Q 

PROVIDER: S-EPMC8581407 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature