CLEC-2-dependent platelet subendothelial accumulation by flow disturbance contributes to atherogenesis in mice.

ABSTRACT: Rationale: Platelets play an essential role in atherosclerosis, but the underlying mechanisms remain to be addressed. This study is to investigate the role of platelets in d-flow induced vascular inflammation and the underlying mechanism. Methods: We established a disturbed blood flow (d-flow) model by partial carotid ligation (PCL) surgery using atherosclerosis-susceptible mice and wild-type mice to observe the d-flow induced platelet accumulation in the subendothelium or in the plaque by immunostaining or transmission electron microscopy. The mechanism of platelet subendothelial accumulation was further explored by specific gene knockout mice. Results: We observed presence of platelets in atherosclerotic plaques either in the atheroprone area of aortic arch or in car

SUBMITTER: Tang C 

PROVIDER: S-EPMC8581433 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature