Metabolomics Study of Guizhi Fuling Capsules in Rats With Cold Coagulation Dysmenorrhea.

ABSTRACT: Dysmenorrhea refers to a kind of uterine cramping pain that occurs in women during the period of menstrual. Guizhi Fuling Capsules are mainly used for the treatment of various pain syndromes and especially effective in treating primary dysmenorrhea. However, the research on its modern pharmacology and mechanism of action have not been thoroughly carried out. It is not clear about the main active ingredients, potential targets and metabolic pathways involved in its efficacy. Therefore, this research project employed estradiol benzoate sensitization combined with oxytocin pain to construct the cold coagulation syndrome dysmenorrhea model, observed the anti-dysmenorrhea effect of Guizhi Fuling Capsules, and used the metabolomics to explore its mechanism. The results showed that Guizhi Fuling

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC8581447 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature