Paediatric serum sickness-like reaction: A 10-year retrospective cohort study.

ABSTRACT:

Background

Serum sickness-like reaction (SSLR) is an acute inflammatory condition affecting predominantly children. The pathophysiology remains unclear, but drugs are considered the main trigger.

Objective

The aim of this study was to describe the clinical and laboratory features, triggers, and treatment modalities in children diagnosed with SSLR.

Methods

We conducted a 10-year retrospective cohort study including all paediatric patients (0 to 18 years old) with query SSLR referred to the Adverse Drug Reactions Clinic at the Children's Hospital of Western Ontario. Diagnostic criteria included acute skin rash plus joint inflammation with or without fever.

Results

We included 83 patients (47 females). Age ranged from 11 months to 12 years (mean 3.2 years). Amoxic

SUBMITTER: Del Pozzo-Magana BR 

PROVIDER: S-EPMC8581535 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature