Spatial Profiles of Intratumoral PD-1⁺ Helper T Cells Predict Prognosis in Head and Neck Squamous Cell Carcinoma.

ABSTRACT:

Background

Functional interactions between immune cells and neoplastic cells in the tumor immune microenvironment have been actively pursued for both biomarker discovery for patient stratification, as well as therapeutic anti-cancer targets to improve clinical outcomes. Although accumulating evidence indicates that intratumoral infiltration of immune cells has prognostic significance, limited information is available on the spatial infiltration patterns of immune cells within intratumoral regions. This study aimed to understand the intratumoral heterogeneity and spatial distribution of immune cell infiltrates associated with cell phenotypes and prognosis in head and neck squamous cell carcinoma (HNSCC).

Methods

A total of 88 specimens of oropharyngeal squamous cell carcinoma

SUBMITTER: Yoshimura K 

PROVIDER: S-EPMC8581667 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature