Sex Differences in Cerebral Small Vessel Disease: A Systematic Review and Meta-Analysis.

ABSTRACT: Background: Cerebral small vessel disease (SVD) is a common cause of stroke, mild cognitive impairment, dementia and physical impairments. Differences in SVD incidence or severity between males and females are unknown. We assessed sex differences in SVD by assessing the male-to-female ratio (M:F) of recruited participants and incidence of SVD, risk factor presence, distribution, and severity of SVD features. Methods: We assessed four recent systematic reviews on SVD and performed a supplementary search of MEDLINE to identify studies reporting M:F ratio in covert, stroke, or cognitive SVD presentations (registered protocol: CRD42020193995). We meta-analyzed differences in sex ratios across time, countries, SVD severity and presentations, age and risk factors for SVD. Result

SUBMITTER: Jimenez-Sanchez L 

PROVIDER: S-EPMC8581736 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature