Inhibition of bone morphogenetic proteins signaling suppresses metastasis melanoma: a proteomics approach.

ABSTRACT:

Background

Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-β superfamily, known to promote the tumor invasion and metastasis. There are continual progresses in understanding the role of BMP signaling pathways in carcinogenesis. However, the biological significance of BMPs in human melanoma has received very little attention. The study aimed to explore the effect of BMP inhibition on melanoma treated with LDN193189 (BMP inhibitor) using a quantitative proteomics approach in a melanoma xenograft model.

Materials and methods

Melanoma tumor was induced in C57BL6 mice and treated intraperitoneally with LDN193189 for ten consecutive days. Post-treatment, tumors were collected, and comparative proteomics was performed using a high-resolution Orbitra

SUBMITTER: Kalal BS 

PROVIDER: S-EPMC8581940 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature