Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Effective detection of bacteria using metal nanoclusters.

ABSTRACT: Antibiotic-resistant bacterial infections cause more than 700 000 deaths each year worldwide. Detection of bacteria is critical in limiting infection-based damage. Nanomaterials provide promising sensing platforms owing to their ability to access new interaction modalities. Nanoclusters feature sizes smaller than traditional nanomaterials, providing great sensitive ability for detecting analytes. The distinct optical and catalytic properties of nanoclusters combined with their biocompatibility enables them as efficient biosensors. In this review, we summarize multiple strategies that utilize nanoclusters for detection of pathogenic bacteria.

SUBMITTER: Li D

PROVIDER: S-EPMC8582014 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Publications

Effective detection of bacteria using metal nanoclusters.

Li Dan D Kumari Beena B Makabenta Jessa Marie JM Gupta Akash A Rotello Vincent V

Nanoscale 20191101 46

Antibiotic-resistant bacterial infections cause more than 700 000 deaths each year worldwide. Detection of bacteria is critical in limiting infection-based damage. Nanomaterials provide promising sensing platforms owing to their ability to access new interaction modalities. Nanoclusters feature sizes smaller than traditional nanomaterials, providing great sensitive ability for detecting analytes. The distinct optical and catalytic properties of nanoclusters combined with their biocompatibility e ...[more]

PMID: 31746916

Similar Datasets

Efficient in vivo wound healing using noble metal nanoclusters.

Project description:The wound healing process involves multiple steps including hemostasis, inflammation, proliferation, and tissue remodeling. Nanomaterials have been employed externally for healing wounds. However, their use as systemic therapeutics has not been extensively explored. We report the use of ultra-small noble metal nanoclusters (NCs) for the treatment of skin wounds. Both in vitro and in vivo studies indicate NCs have comprehensive therapeutic effects for wound healing, promoting cell proliferation and migration while decreasing inflammation.

| S-EPMC8084111 | biostudies-literature

Thumb Imprint Based Detection of Hyperbilirubinemia Using Luminescent Gold Nanoclusters.

Project description:Early and easy detection of diseases, using point-of-care and inexpensive devices, not only provides option for early treatment but also reduces the risk of propagation. Herein we report the fabrication of a robust film based luminescence indicator of bilirubin, which can indicate hyperbilirubinemia through the thumb imprint of the patient. The UV-light induced luminescence intensity of the film, made out of chitosan stabilised gold (Au) nanoclusters, which was effectively quenched in the presence of Cu2+ ions, recovered in the presence of bilirubin from skin or blood serum. Moreover, the sensitivity of detection of bilirubin was tuneable with the amount of Cu2+ added, thereby facilitating the detection of the desired concentration range of bilirubin.

| S-EPMC5157017 | biostudies-literature

Effective Detection of Variation in Single Cell Transcriptome using MATQ-seq

Project description:We report here a new single-cell RNA-seq assay, Multiple Annealing and dC-Tailing based Quantitative single-cell RNA-seq (MATQ-seq), which provides the accuracy and sensitivity that enable the detection of transcriptional variations existing in single cells of the same type. We performed a systematic characterization of the technical noise using pool-and-split averaged single-cell samples and showed that the biological variations in single cells were observed with statistical significance.

2016-12-31 | GSE78968 | GEO

Nanohybrids of atomically precise metal nanoclusters.

Project description:Atomically precise metal nanoclusters (NCs) with molecule-like structures are emerging nanomaterials with fascinating chemical and physical properties. Photoluminescence (PL), catalysis, sensing, etc., are some of the most intriguing and promising properties of NCs, making the metal NCs potentially beneficial in different applications. However, long-term instability under ambient conditions is often considered the primary barrier to translational research in the relevant application fields. Creating nanohybrids between such atomically precise NCs and other stable nanomaterials (0, 1, 2, or 3D) can help expand their applicability. Many such recently reported nanohybrids have gained promising attention as a new class of materials in the application field, exhibiting better stability and exciting properties of interest. This perspective highlights such nanohybrids and briefly explains their exciting properties. These hybrids are categorized based on the interactions between the NCs and other materials, such as metal-ligand covalent interactions, hydrogen-bonding, host-guest, hydrophobic, and electrostatic interactions during the formation of nanohybrids. This perspective will also capture some of the new possibilities with such nanohybrids.

| S-EPMC10372104 | biostudies-literature

Thermodynamic stability of ligand-protected metal nanoclusters.

Project description:Despite the great advances in synthesis and structural determination of atomically precise, thiolate-protected metal nanoclusters, our understanding of the driving forces for their colloidal stabilization is very limited. Currently there is a lack of models able to describe the thermodynamic stability of these 'magic-number' colloidal nanoclusters as a function of their atomic-level structural characteristics. Herein, we introduce the thermodynamic stability theory, derived from first principles, which is able to address stability of thiolate-protected metal nanoclusters as a function of the number of metal core atoms and thiolates on the nanocluster shell. Surprisingly, we reveal a fine energy balance between the core cohesive energy and the shell-to-core binding energy that appears to drive nanocluster stabilization. Our theory applies to both charged and neutral systems and captures a large number of experimental observations. Importantly, it opens new avenues for accelerating the discovery of stable, atomically precise, colloidal metal nanoclusters.

| S-EPMC5504301 | biostudies-literature

Detection of Phenylalanine by Iridium Nanoclusters Using Time-Dependent Density Functional Theory Calculations.

Project description:Metal nanoclusters have several applications in biological processes, medicine, cancer therapy, catalysis, etc. Iridium (Ir) nanoclusters exhibit excellent detection behavior compared to their bulk material. This work includes a deep insight into the interaction of Ir nanoclusters of four atoms (Ir4) with amino acids and the analysis of Ir-amino acid (Ir-AAc) complexes. UV-visible spectroscopy of the Ir4 nanocluster, amino acids, and their complexes was discussed as a way to detect amino acids with the help of the Ir4 nanocluster. In UV-visible analysis, the UV-visible peak of phenylalanine (Phe) appeared at 204 nm with an excitation energy of 6.02 eV with a 0.0516 oscillator strength. Meanwhile, only in the Ir4 nanocluster-phenylalanine (Ir-Phe) complex, the UV-visible peak was observed at 661 nm with an excitation energy of 1.87 eV and oscillator strength of 0.0051. This peak was observed due to the transition from HOMO-1 to LUMO+3. In the other complexes, no UV-visible peaks are observed. Thus, the results predict that the Ir4 nanocluster can be used in the detection of Phe via UV-visible spectra.

| S-EPMC11391552 | biostudies-literature

Phosphorescent Metal Halide Nanoclusters for Tunable Photodynamic Therapy.

Project description:Photodynamic therapy (PDT) is currently limited by the inability of photosensitizers (PSs) to enter cancer cells and generate sufficient reactive oxygen species. Utilizing phosphorescent triplet states of novel PSs to generate singlet oxygen offers exciting possibilities for PDT. Here, we report phosphorescent octahedral molybdenum (Mo)-based nanoclusters (NC) with tunable toxicity for PDT of cancer cells without use of rare or toxic elements. Upon irradiation with blue light, these molecules are excited to their singlet state and then undergo intersystem crossing to their triplet state. These NCs display surprising tunability between their cellular cytotoxicity and phototoxicity by modulating the apical halide ligand with a series of short chain fatty acids from trifluoroacetate to heptafluorobutyrate. The NCs are effective in PDT against breast, skin, pancreas, and colon cancer cells as well as their highly metastatic derivatives, demonstrating the robustness of these NCs in treating a wide variety of aggressive cancer cells. Furthermore, these NCs are internalized by cancer cells, remain in the lysosome, and can be modulated by the apical ligand to produce singlet oxygen. Thus, (Mo)-based nanoclusters are an excellent platform for optimizing PSs. Our results highlight the profound impact of molecular nanocluster chemistry in PDT applications.

| S-EPMC9898232 | biostudies-literature

Thiacalix[4]arene: New protection for metal nanoclusters.

Project description:Surface organic ligands are critical for the formation and properties of atomically precise metal nanoclusters. In contrast to the conventionally used protective ligands such as thiolates and phosphines, thiacalix[4]arene has been used in the synthesis of a silver nanocluster, [Ag35(H2L)2(L)(C≡CBu(t))16](SbF6)3, (H4L, p-tert-butylthiacalix[4]-arene). This is the first structurally determined calixarene-protected metal nanocluster. The chelating and macrocyclic effects make the thiacalix[4]arene a rigid shell that protects the silver core. Upon addition or removal of one silver atom, the Ag35 cluster can be transformed to Ag36 or Ag34 species, and the optical properties are changed accordingly. The successful use of thiacalixarene in the synthesis of well-defined silver nanoclusters suggests a bright future for metal nanoclusters protected by macrocyclic ligands.

| S-EPMC4982710 | biostudies-literature

Restriction of intramolecular rotation for functionalizing metal nanoclusters.

Project description:The restriction of intramolecular rotation has been extensively exploited to trigger the property enhancement of nanocluster-based materials. However, such a restriction is induced mainly by intermolecular aggregation. The direct restriction of intramolecular rotation of metal nanoclusters, which could boost their properties at the single molecular level, remains rarely explored. Here, ligand engineering was applied to activate intramolecular interactions at the interface between peripheral ligands and metallic kernels of metal nanoclusters. For the newly reported Au4Ag13(SPhCl2)9(DPPM)3 nanocluster, the molecule-level interactions between the Cl terminals on thiol ligands and the Ag atoms on the cluster kernel remarkably restricted the intramolecular rotation, endowing this robust nanocluster with superior thermal stability, emission intensity, and non-linear optical properties over its cluster analogue. This work presents a novel case of the restriction of intramolecular rotation (i.e., intramolecular interaction-induced property enhancement) for functionalizing metal clusters at the single molecular level.

| S-EPMC10430645 | biostudies-literature

Quantum Mechanical Modeling of the Interactions between Noble Metal (Ag and Au) Nanoclusters and Water with the Effective Fragment Potential Method.

Project description:Explicit solvent interactions can significantly alter the physical and chemical properties of noble metal (e.g., gold and silver) nanoclusters. In order to compute these solvent interactions at a reasonable computational cost, a quantum mechanical (QM)/molecular mechanics (MM) approach, where the metal nanocluster is treated with full QM and the water molecules are treated with a MM force field, can be used. However, classical MM force fields were typically parameterized using molecules containing main group elements as the reference. The accuracy of noble metal-solvent interactions obtained with these force fields therefore remains unpredictable. The effective fragment potential (EFP) force field, designed to model explicitly solvated systems, represents an attractive method to simulate solvated noble metal nanoclusters because it is derived from first principles and contains few or no fitted parameters, depending on implementation. At the density functional theory-optimized geometries, good correlation is obtained between the nanocluster-water interaction energies computed with EFP and those computed with the reference coupled cluster singles, doubles, and perturbative triples method. It is shown that the EFP method gives qualitatively accurate interaction energies at medium-large intermolecular distances for various molecular configurations. In order to achieve higher quantitative accuracy, the first solvation shell should be treated with full QM, if possible. EFP is therefore a promising method for the QM modeling of explicitly solvated silver and gold nanoclusters.

| S-EPMC7144145 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data