Substituent Effects on the Basicity of Patriscabrin A and Lettucenin A: Evolution Favors the Aromatic?
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ABSTRACT:
SUBMITTER: Prasad S
PROVIDER: S-EPMC8582057 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
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Substituent Effects on the Basicity of Patriscabrin A and Lettucenin A: Evolution Favors the Aromatic?
Prasad Supreeth S Tantillo Dean J DJ
ACS omega 20211029 44
Basicities for derivatives of patriscabrin A and lettucenin A were calculated with density functional theory. A significant correlation is observed between the basicity and Hammett σ parameters. Protonation increases the aromatic character of the cyclic moieties of each natural product. The naturally occurring structures are predicted to be the most aromatic. ...[more]
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