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Efficient Synthesis of Potential Impurities in Levonadifloxacin (WCK 771).

ABSTRACT: Levonadifloxacin (WCK 771) is a novel broad-spectrum anti-methicillin-resistant Staphylococcus aureus (MRSA) agent recently launched in India. Five process impurities and one degradation impurity were synthesized as reference standards for their quantification by high-performance liquid chromatography (HPLC) methodology in drug substance and drug product. These compounds are not easily commercially available. The synthesis and characterization of these impurities are discussed in detail.

SUBMITTER: Kilbile JT

PROVIDER: S-EPMC8582070 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature

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Efficient Synthesis of Potential Impurities in Levonadifloxacin (WCK 771).

Kilbile Jaydeo T JT Tamboli Yasinalli Y Rafeeq Mohammad M Yadav Ram Prasad RP Rane Vipul P VP Bhamare Vijay S VS Merwade Arvind Y AY

ACS omega 20211027 44

Levonadifloxacin (WCK 771) is a novel broad-spectrum anti-methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) agent recently launched in India. Five process impurities and one degradation impurity were synthesized as reference standards for their quantification by high-performance liquid chromatography (HPLC) methodology in drug substance and drug product. These compounds are not easily commercially available. The synthesis and characterization of these impurities are discussed in detail. ...[more]

PMID: 34778670

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