Causal variants in Maturity Onset Diabetes of the Young (MODY) - A systematic review.

ABSTRACT:

Background

Maturity Onset Diabetes of the Young (MODY) is an autosomal dominant type of diabetes. Pathogenic variants in fourteen genes are reported as causes of MODY. Its symptoms overlap with type 1 and type 2 diabetes. Reviews for clinical characteristics, diagnosis and treatments are available but a comprehensive list of genetic variants, is lacking. Therefore this study was designed to collect all the causal variants involved in MODY, reported to date.

Methods

We searched PubMed from its date of inception to December 2019. The search terms we used included disease names and name of all the known genes involved. The ClinVar database was also searched for causal variants in the known 14 MODY genes.

Results

The record revealed 1647 studies and among them, 326 studie

SUBMITTER: Rafique I 

PROVIDER: S-EPMC8582101 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature