Curcumin prevents As³⁺-induced carcinogenesis through regulation of GSK3β/Nrf2.

ABSTRACT:

Background

Arsenic (As³⁺) is a carcinogen with considerable environmental and occupational relevancy. Its mechanism of action and methods of prevention remain to be investigated. Previous studies have demonstrated that ROS is responsible for As³⁺-induced cell transformation, which is considered as the first stage of As³⁺ carcinogenesis. The NF-E2 p45-related factor-2 (Nrf2) signaling pathway regulates the cellular antioxidant response, and activation of Nrf2 has recently been shown to limit oxidative damage following exposure to As³⁺ METHODS AND RESULTS: In this study, molecular docking was used to virtually screen natural antioxidant chemical databases and identify molecules that interact with the ligand-binding site of Keap1 (PDB code 4

SUBMITTER: Dang YY 

PROVIDER: S-EPMC8582166 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature