Synthaser: a CD-Search enabled Python toolkit for analysing domain architecture of fungal secondary metabolite megasynth(et)ases.

ABSTRACT:

Background

Fungi are prolific producers of secondary metabolites (SMs), which are bioactive small molecules with important applications in medicine, agriculture and other industries. The backbones of a large proportion of fungal SMs are generated through the action of large, multi-domain megasynth(et)ases such as polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs). The structure of these backbones is determined by the domain architecture of the corresponding megasynth(et)ase, and thus accurate annotation and classification of these architectures is an important step in linking SMs to their biosynthetic origins in the genome.

Results

Here we report synthaser, a Python package leveraging the NCBI's conserved domain search tool for remote prediction and cla

SUBMITTER: Gilchrist CLM 

PROVIDER: S-EPMC8582187 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature