Epigenetic glycosylation of SARS-CoV-2 impact viral infection through DC&L-SIGN receptors.
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ABSTRACT:
SUBMITTER: Guo L
PROVIDER: S-EPMC8582233 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Publications
Epigenetic glycosylation of SARS-CoV-2 impact viral infection through DC&L-SIGN receptors.
Guo Lei L Liang Yan Y Li Heng H Zheng Huiwen H Yang Zening Z Chen Yanli Y Zhao Xin X Li Jing J Li Binxiang B Shi Haijing H Sun Ming M Liu Longding L
iScience 20211111 12
Glycosylation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein mediates viral entry and immune escape. While glycan site is determined by viral genetic code, glycosylation is completely dependent on host cell post-translational modification. Here, by producing SARS-CoV-2 virions from various host cell lines, viruses of different origins with diverse spike protein glycan patterns were revealed. Binding affinities to C-type lectin receptors (CLRs) DC&L-SIGN differ ...[more]
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