Differential Effects of a Nap on Motor Sequence Learning-Related Functional Connectivity Between Young and Older Adults.

ABSTRACT: In older adults, motor sequence learning (MSL) is largely intact. However, consolidation of newly learned motor sequences is impaired compared to younger adults, and there is evidence that brain areas supporting enhanced consolidation via sleep degrade with age. It is known that brain activity in hippocampal-cortical-striatal areas is important for sleep-dependent, off-line consolidation of motor-sequences. Yet, the intricacies of how both age and sleep alter communication within this network of brain areas, which facilitate consolidation, are not known. In this study, 37 young (age 20-35) and 49 older individuals (age 55-75) underwent resting state functional magnetic resonance imaging (fMRI) before and after training on a MSL task as well as after either a nap or a period of awake

SUBMITTER: Fang Z 

PROVIDER: S-EPMC8582327 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature