Author Correction: Isolation of SARS-CoV-2-related coronavirus from Malayan pangolins.
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ABSTRACT:
SUBMITTER: Xiao K
PROVIDER: S-EPMC8582334 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Publications
Author Correction: Isolation of SARS-CoV-2-related coronavirus from Malayan pangolins.
Xiao Kangpeng K Zhai Junqiong J Feng Yaoyu Y Zhou Niu N Zhang Xu X Zou Jie-Jian JJ Li Na N Guo Yaqiong Y Li Xiaobing X Shen Xuejuan X Zhang Zhipeng Z Shu Fanfan F Huang Wanyi W Li Yu Y Zhang Ziding Z Chen Rui-Ai RA Wu Ya-Jiang YJ Peng Shi-Ming SM Huang Mian M Xie Wei-Jun WJ Cai Qin-Hui QH Hou Fang-Hui FH Chen Wu W Xiao Lihua L Shen Yongyi Y
Nature 20211201 7887
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Project description:[This corrects the article DOI: 10.1371/journal.ppat.1008421.].
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Project description:Malayan pangolin SARS-CoV-2-related coronavirus (SARSr-CoV-2) is closely related to SARS-CoV-2. However, little is known about its pathogenicity in pangolins. Using CT scans we show that SARSr-CoV-2 positive Malayan pangolins are characterized by bilateral ground-glass opacities in lungs in a similar manner to COVID-19 patients. Histological examination and blood gas tests are indicative of dyspnea. SARSr-CoV-2 infected multiple organs in pangolins, with the lungs the major target, and histological expression data revealed that ACE2 and TMPRSS2 were co-expressed with viral RNA. Transcriptome analysis indicated that virus-positive pangolins were likely to have inadequate interferon responses, with relative greater cytokine and chemokine activity in the lung and spleen. Notably, both viral RNA and viral proteins were detected in three pangolin fetuses, providing initial evidence for vertical virus transmission. In sum, our study outlines the biological framework of SARSr-CoV-2 in pangolins, revealing striking similarities to COVID-19 in humans.
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Project description:An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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