Anticancer Activity of Biogenic Selenium Nanoparticles: Apoptotic and Immunogenic Cell Death Markers in Colon Cancer Cells.

ABSTRACT: Colorectal cancer is a health problem with high mortality rates and prevalence. Thus, innovative treatment approaches need to be developed. Biogenic nanoparticles are nanomaterials that can be synthesised in biological systems and, compared to chemically synthesised nanoparticles, have better bioavailability while being more cost-effective, eco-friendlier, and less toxic. In our previous studies, the probiotic strain Lactobacillus casei ATCC 393 was used to synthesise selenium nanoparticles (SeNps), which were shown to inhibit colon cancer cell growth in vitro and in vivo. Herein, we have further investigated SeNps' pro-apoptotic activity and their ability to induce immunogenic cell death (ICD) in colon cancer cells. The SeNps' effect on Caco-2 cells growth was examined along with their po

SUBMITTER: Spyridopoulou K 

PROVIDER: S-EPMC8582357 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature