Molecular-Genetic Portrait of Breast Cancer with Triple Negative Phenotype.

ABSTRACT: Understanding of the genetic mechanisms and identification of the biological markers of tumor progression that form the individual molecular phenotype of transformed cells can characterize the degree of tumor malignancy, the ability to metastasize, the hormonal sensitivity, and the effectiveness of chemotherapy, etc. Breast cancer (BC) is a genetically heterogeneous disease with different molecular biological and clinical characteristics. The available knowledge about the genetic heterogeneity of the most aggressive molecular subtype of breast cancer-triple-negative (TN)-has led to discoveries in drug treatment, including the use of DNA damaging agents (platinum and PARP inhibitors) for these tumors, as well as the use of immunotherapy. Most importantly, the ability to prescribe optimal dr

SUBMITTER: Ibragimova MK 

PROVIDER: S-EPMC8582512 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature