Dataset Information

Interplay between IL-10, IFN-γ, IL-17A and PD-1 Expressing EBNA1-Specific CD4⁺ and CD8⁺ T Cell Responses in the Etiologic Pathway to Endemic Burkitt Lymphoma.

ABSTRACT: Children diagnosed with endemic Burkitt lymphoma (eBL) are deficient in interferon-γ (IFN-γ) responses to Epstein-Barr Nuclear Antigen1 (EBNA1), the viral protein that defines the latency I pattern in this B cell tumor. However, the contributions of immune-regulatory cytokines and phenotypes of the EBNA1-specific T cells have not been characterized for eBL. Using a bespoke flow cytometry assay we measured intracellular IFN-γ, IL-10, IL-17A expression and phenotyped CD4⁺ and CD8⁺ T cell effector memory subsets specific to EBNA1 for eBL patients compared to two groups of healthy children with divergent malaria exposures. In response to EBNA1 and a malaria antigen (PfSEA-1A), the three study groups exhibited strikingly different cytokine expression and T cell memo

SUBMITTER: Forconi CS

PROVIDER: S-EPMC8582526 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature

ACCESS DATA

Dataset Information

Interplay between IL-10, IFN-γ, IL-17A and PD-1 Expressing EBNA1-Specific CD4⁺ and CD8⁺ T Cell Responses in the Etiologic Pathway to Endemic Burkitt Lymphoma.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Interplay between IL-10, IFN-γ, IL-17A and PD-1 Expressing EBNA1-Specific CD4+ and CD8+ T Cell Responses in the Etiologic Pathway to Endemic Burkitt Lymphoma.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Interplay between IL-10, IFN-γ, IL-17A and PD-1 Expressing EBNA1-Specific CD4⁺ and CD8⁺ T Cell Responses in the Etiologic Pathway to Endemic Burkitt Lymphoma.