Multi-Omics Analysis of Glioblastoma Cells' Sensitivity to Oncolytic Viruses.

ABSTRACT: Oncolytic viruses have gained momentum in the last decades as a promising tool for cancer treatment. Despite the progress, only a fraction of patients show a positive response to viral therapy. One of the key variable factors contributing to therapy outcomes is interferon-dependent antiviral mechanisms in tumor cells. Here, we evaluated this factor using patient-derived glioblastoma multiforme (GBM) cultures. Cell response to the type I interferons' (IFNs) stimulation was characterized at mRNA and protein levels. Omics analysis revealed that GBM cells overexpress interferon-stimulated genes (ISGs) and upregulate their proteins, similar to the normal cells. A conserved molecular pattern unambiguously differentiates between the preserved and defective responses. Comparing ISGs' portraits wit

SUBMITTER: Lipatova AV 

PROVIDER: S-EPMC8582528 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature