Targeted Deep Sequencing of Mycosis Fungoides Reveals Intracellular Signaling Pathways Associated with Aggressiveness and Large Cell Transformation.

ABSTRACT:

Introduction

Large-cell transformation (LCT) of mycosis fungoides (MF) has been associated with a higher risk of relapse and progression and, consequently, restricted prognosis. Its molecular pathogenesis has not been elucidated yet.

Materials and methods

In order to address molecular mechanisms of LCT, we performed hybrid capture panel-based sequencing of skin biopsies from 10 patients suffering from MF with LCT versus 17 patients without LCT including follow-up biopsies during clinical course, respectively (51 samples in total). The analyzed patients were attributed to three different groups based on the presence of LCT and clinical behavior.

Results

While indolent MF cases without LCT did not show pathogenic driver mutations, a high rate of oncogenic alterations wa

SUBMITTER: Wobser M 

PROVIDER: S-EPMC8582785 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature