ERAS, a Member of the Ras Superfamily, Acts as an Oncoprotein in the Mammary Gland.

ABSTRACT: ERAS is a relatively uncharacterized gene of the Ras superfamily. It is expressed in ES cells and in the first stages of embryonic development; later on, it is silenced in the majority of cell types and tissues. Although there are several reports showing ERAS expression in tumoral cell lines and human tumor samples, it is unknown if ERAS deregulated expression is enough to drive tumor development. In this report, we have generated transgenic mice expressing ERAS in myoepithelial basal cells of the mammary gland and in basal cells of stratified epithelia. In spite of the low level of ERAS expression, these transgenic mice showed phenotypic alterations resembling overgrowth syndromes caused by the activation of the AKT-PI3K pathway. In addition, their mammary glands present developmental and

SUBMITTER: Suarez-Cabrera C 

PROVIDER: S-EPMC8582886 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature