A Prostate Cancer Proteomics Database for SWATH-MS Based Protein Quantification.

ABSTRACT: Prostate cancer is the most frequent form of cancer in men, accounting for more than one-third of all cases. Current screening techniques, such as PSA testing used in conjunction with routine procedures, lead to unnecessary biopsies and the discovery of low-risk tumours, resulting in overdiagnosis. SWATH-MS is a well-established data-independent (DI) method requiring prior knowledge of targeted peptides to obtain valuable information from SWATH maps. In response to the growing need to identify and characterise protein biomarkers for prostate cancer, this study explored a spectrum source for targeted proteome analysis of blood samples. We created a comprehensive prostate cancer serum spectral library by combining data-dependent acquisition (DDA) MS raw files from 504 patients with low, inte

SUBMITTER: Muazzam A 

PROVIDER: S-EPMC8582933 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature