Effects of fecal microbiota transplant on DNA methylation in subjects with metabolic syndrome.

ABSTRACT: Accumulating evidence shows that microbes with their theater of activity residing within the human intestinal tract (i.e., the gut microbiome) influence host metabolism. Some of the strongest results come from recent fecal microbial transplant (FMT) studies that relate changes in intestinal microbiota to various markers of metabolism as well as the pathophysiology of insulin resistance. Despite these developments, there is still a limited understanding of the multitude of effects associated with FMT on the general physiology of the host, beyond changes in gut microbiome composition. We examined the effect of either allogenic (lean donor) or autologous FMTs on the gut microbiome, plasma metabolome, and epigenomic (DNA methylation) reprogramming in peripheral blood mononuclear cells in indiv

SUBMITTER: van der Vossen EWJ 

PROVIDER: S-EPMC8583152 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature