Naturalizing laboratory mice by housing in a farmyard-type habitat confers protection against colorectal carcinogenesis.

ABSTRACT: Living in a farm environment in proximity to animals is associated with reduced risk of developing allergies and asthma, and has been suggested to protect against other diseases, such as inflammatory bowel disease and cancer. Despite epidemiological evidence, experimental disease models that recapitulate such environments are needed to understand the underlying mechanisms. In this study, we show that feralizing conventional inbred mice by continuous exposure to a livestock farmyard-type environment conferred protection toward colorectal carcinogenesis. Two independent experimental approaches for colorectal cancer induction were used; spontaneous (Apc Min/+ mice on an A/J background) or chemical (AOM/DSS). In contrast to conventionally reared laboratory mice, the feralized mouse gut microbi

SUBMITTER: Arnesen H 

PROVIDER: S-EPMC8583187 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature