Long non-coding RNA NEAT1_1 ameliorates TDP-43 toxicity in in vivo models of TDP-43 proteinopathy.
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ABSTRACT:
SUBMITTER: Matsukawa K
PROVIDER: S-EPMC8583295 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Publications
Long non-coding RNA NEAT1_1 ameliorates TDP-43 toxicity in in vivo models of TDP-43 proteinopathy.
Matsukawa Koji K Kukharsky Michail S MS Park Sei-Kyoung SK Park Sangeun S Watanabe Naruaki N Iwatsubo Takeshi T Hashimoto Tadafumi T Liebman Susan W SW Shelkovnikova Tatyana A TA
RNA biology 20210111 11
Pathological changes involving TDP-43 protein ('TDP-43 proteinopathy') are typical for several neurodegenerative diseases, including frontotemporal lobar degeneration (FTLD). FTLD-TDP cases are characterized by increased binding of TDP-43 to an abundant lncRNA, NEAT1, in the cortex. However it is unclear whether enhanced TDP-43-NEAT1 interaction represents a protective mechanism. We show that accumulation of human TDP-43 leads to upregulation of the constitutive NEAT1 isoform, NEAT1_1, in cultur ...[more]
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