Dissecting the Biological Relevance and Clinical Impact of lncRNA MIAT in Multiple Myeloma.

ABSTRACT: The biological impact of long non-coding RNAs (lncRNAs) in multiple myeloma (MM) is becoming an essential aspect of the investigation, which may contribute to understanding the disease's complex pathobiology, providing novel potential therapeutic targets. Herein, we investigated the expression pattern and the clinical relevance of the lncRNA MIAT in MM, taking advantage of the publicly available CoMMpass database. MIAT expression in MM is highly heterogeneous and significantly associated with specific molecular lesions frequently occurring in MM. Transcriptome analyses of MM PCs from patients included in the CoMMpass database indicated a potential involvement of MIAT in different signaling pathways and ribosome biogenesis and assembly. These findings suggest that MIAT deregulation may play

SUBMITTER: Todoerti K 

PROVIDER: S-EPMC8583301 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature