WNT/β-Catenin Pathway in Soft Tissue Sarcomas: New Therapeutic Opportunities?

ABSTRACT: Soft tissue sarcomas (STS) are a very heterogeneous group of rare tumors, comprising more than 50 different histological subtypes that originate from mesenchymal tissue. Despite their heterogeneity, chemotherapy based on doxorubicin (DXR) has been in use for forty years now and remains the standard first-line treatment for locally advanced unresectable or metastatic STS, although overall survival could not be improved by combination with other chemotherapeutics. In this sense, the development of new therapeutic approaches continues to be a largely unmatched goal. The WNT/β-catenin signaling pathway is involved in various fundamental processes for embryogenic development, including the proliferation and differentiation of mesenchymal stem cells. Although the role of this pathway has been wi

SUBMITTER: Martinez-Font E 

PROVIDER: S-EPMC8583315 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature