Genome-wide association study of serum metabolites in the African American Study of Kidney Disease and Hypertension.

ABSTRACT: The genome-wide association study (GWAS) is a powerful means to study genetic determinants of disease traits and generate insights into disease pathophysiology. To date, few GWAS of circulating metabolite levels have been performed in African Americans with chronic kidney disease. Hypothesizing that novel genetic-metabolite associations may be identified in a unique population of African Americans with a lower glomerular filtration rate (GFR), we conducted a GWAS of 652 serum metabolites in 619 participants (mean measured glomerular filtration rate 45 mL/min/1.73m²) in the African American Study of Kidney Disease and Hypertension, a clinical trial of blood pressure lowering and antihypertensive medication in African Americans with chronic kidney disease. We identified 42 signifi

SUBMITTER: Luo S 

PROVIDER: S-EPMC8583323 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature