Cognitive performance declines in older adults with type 1 diabetes: results from 32 years of follow-up in the DCCT and EDIC Study.

ABSTRACT:

Background

With improved treatment, individuals with type 1 diabetes are living longer but there is limited information on the effects of type 1 diabetes on cognitive ability as they become older adults. We followed up individuals with type 1 diabetes to identify independent risk factors for cognitive decline as people age.

Methods

1051 participants with type 1 diabetes enrolled in the Diabetes Control and Complications Trial (DCCT) and its follow-up Epidemiology of Diabetes Interventions and Complications (EDIC) study. Participants completed cognitive assessments at baseline (median age 27 years) and 2, 5, 18, and 32 years later (median age 59). HbA_1c levels, frequency of severe hypoglycaemia, non-glycemic risk factors such as elevated blood pressure, and microva

SUBMITTER: Jacobson AM 

PROVIDER: S-EPMC8583716 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature