The Role of TP53 in Cisplatin Resistance in Mediastinal and Testicular Germ Cell Tumors.

ABSTRACT: Germ cell tumors (GCTs) are considered to be highly curable; however, there are major differences in the outcomes related to histology and anatomical localization. GCTs originating from the testis are, overall, sensitive to platinum-based chemotherapy, whereas GCTs originating from the mediastinum show a worse response, which remains largely unexplained. Here, we address the differences among GCTs from two different anatomical locations (testicular versus mediastinal/extragonadal), with a specific focus on the role of the P53 pathway. It was recently shown that GCTs with TP53 mutations most often localize to the mediastinum. To elucidate the underlying mechanism, TP53 knock-out lines were generated in cisplatin-sensitive and -resistant clones of the representative 2102Ep cell

SUBMITTER: Timmerman DM 

PROVIDER: S-EPMC8583723 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature