Design of High-Relaxivity Polyelectrolyte Nanocapsules Based on Citrate Complexes of Gadolinium(III) of Unusual Composition.

ABSTRACT: Through nuclear magnetic relaxation and pH-metry, the details of the complexation of gadolinium(III) ions with citric acid (H4L) in water and aqueous solutions of cationic polyelectrolytes are established. It is shown that the presence of poly(ethylene imine) (PEI) in solution affects magnetic relaxation behavior of gadolinium(III) complexes with citric acid (Cit) to a greater extent than polydiallyldimethylammonium chloride (PDDC). A large increase in relaxivity (up to 50 mM-1s-1) in the broad pH range (4-8) is revealed for the gadolinium(III)-citric acid-PEI system, which is particularly strong in the case of PEI with the molecular weight of 25 and 60 kDa. In weakly acidic medium (pH 3-7), the presence of PEI results in the formation of two tris-ligand associates [Gd(H2L)3]3- and [Gd(H2L

SUBMITTER: Burilova E 

PROVIDER: S-EPMC8583736 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature