Growth of Biological Complexity from Prokaryotes to Hominids Reflected in the Human Genome.

ABSTRACT: The growth of complexity in evolution is a most intriguing phenomenon. Using gene phylostratigraphy, we showed this growth (as reflected in regulatory mechanisms) in the human genome, tracing the path from prokaryotes to hominids. Generally, the different regulatory gene families expanded at different times, yet only up to the Euteleostomi (bony vertebrates). The only exception was the expansion of transcription factors (TF) in placentals; however, we argue that this was not related to increase in general complexity. Surprisingly, although TF originated in the Prokaryota while chromatin appeared only in the Eukaryota, the expansion of epigenetic factors predated the expansion of TF. Signaling receptors, tumor suppressors, oncogenes, and aging- and disease-associated genes (indicating vulne

SUBMITTER: Vinogradov AE 

PROVIDER: S-EPMC8583824 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature