Ontology highlight
ABSTRACT:
SUBMITTER: Okada M
PROVIDER: S-EPMC8583947 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Okada Masashi M Suzuki Shuhei S Togashi Keita K Sugai Asuka A Yamamoto Masahiro M Kitanaka Chifumi C
International journal of molecular sciences 20211027 21
Glioblastoma (GBM) is one of the deadliest of all human cancers. Developing therapies targeting GBM cancer stem cells or glioma stem cells (GSCs), which are deemed responsible for the malignancy of GBM due to their therapy resistance and tumor-initiating capacity, is considered key to improving the dismal prognosis of GBM patients. In this study, we found that folate antagonists, such as methotrexate (MTX) and pemetrexed, are selectively cytotoxic to GSCs, but not to their differentiated counter ...[more]