Ontology highlight
ABSTRACT:
SUBMITTER: Kikuchi K
PROVIDER: S-EPMC8584075 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
International journal of molecular sciences 20211027 21
The potent splicing inhibitor spliceostatin A (SSA) inhibits cell cycle progression at the G1 and G2/M phases. We previously reported that upregulation of the p27 cyclin-dependent kinase inhibitor encoded by <i>CDKN1B</i> and its C-terminal truncated form, namely p27*, which is translated from <i>CDKN1B</i> pre-mRNA, is one of the causes of G1 phase arrest caused by SSA treatment. However, the detailed molecular mechanism underlying G1 phase arrest caused by SSA treatment remains to be elucidate ...[more]