Chronic Exposure to Paraquat Induces Alpha-Synuclein Pathogenic Modifications in Drosophila.

ABSTRACT: Parkinson's disease (PD) is characterized by the progressive accumulation of neuronal intracellular aggregates largely composed of alpha-Synuclein (αSyn) protein. The process of αSyn aggregation is induced during aging and enhanced by environmental stresses, such as the exposure to pesticides. Paraquat (PQ) is an herbicide which has been widely used in agriculture and associated with PD. PQ is known to cause an increased oxidative stress in exposed individuals but the consequences of such stress on αSyn conformation remains poorly understood. To study αSyn pathogenic modifications in response to PQ, we exposed Drosophila expressing human αSyn to a chronic PQ protocol. We first showed that PQ exposure and αSyn expression synergistically induced fly mortality. The exposure to PQ was a

SUBMITTER: Arsac JN 

PROVIDER: S-EPMC8584077 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature