Regulation of p27 and Cdk2 Expression in Different Adipose Tissue Depots in Aging and Obesity.

ABSTRACT: Aging usually comes associated with increased visceral fat accumulation, reaching even an obesity state, and favoring its associated comorbidities. One of the processes involved in aging is cellular senescence, which is highly dependent on the activity of the regulators of the cell cycle. The aim of this study was to analyze the changes in the expression of p27 and cdk2 in different adipose tissue depots during aging, as well as their regulation by obesity in mice. Changes in the expression of p27 and CDK2 in visceral and subcutaneous white adipose tissue (WAT) biopsies were also analyzed in a human cohort of obesity and type 2 diabetes. p27, but not cdk2, exhibits a lower expression in subcutaneous than in visceral WAT in mice and humans. p27 is drastically downregulated by aging in subcu

SUBMITTER: Colon-Mesa I 

PROVIDER: S-EPMC8584112 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature