Glutamate and GABA in Microglia-Neuron Cross-Talk in Alzheimer's Disease.

ABSTRACT: The physiological balance between excitation and inhibition in the brain is significantly affected in Alzheimer's disease (AD). Several neuroactive compounds and their signaling pathways through various types of receptors are crucial in brain homeostasis, among them glutamate and γ-aminobutyric acid (GABA). Activation of microglial receptors regulates the immunological response of these cells, which in AD could be neuroprotective or neurotoxic. The novel research approaches revealed the complexity of microglial function, including the interplay with other cells during neuroinflammation and in the AD brain. The purpose of this review is to describe the role of several proteins and multiple receptors on microglia and neurons, and their involvement in a communication network between cells tha

SUBMITTER: Czapski GA 

PROVIDER: S-EPMC8584169 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature